Bilirubin, a curse and a boon

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Bilirubin, a curse and a boon.

B oth hydrophobic bile salts 2 and unconjugated bilirubin (UCB) induce apoptosis in cultured cells at moderately elevated concentrations and cell necrosis at higher concentrations. Retention of bile salts in cholestasis is believed to cause secondary damage to hepatocytes, and retention of UCB in severe neonatal jaundice is known to cause bilirubin encephalopathy. For both agents, the cytotoxic...

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ژورنال

عنوان ژورنال: Gut

سال: 2003

ISSN: 0017-5749

DOI: 10.1136/gut.52.12.1668